Disease Publications

Hoskinson C, Dai DLY, Del Bel KL, Becker AB, Moraes TJ, Mandhane PJ, Finlay BB, Simons E, Kozyrskyj AL, Azad MB, Subbarao P, Petersen C, Turvey SE. Nat Commun. 2023 Aug 29;14(1):4785. doi: 10.1038/s41467-023-40336-4. PMID: 37644001; PMCID: PMC10465508.

Wang K, Khoramjoo M, Srinivasan K, Gordon PMK, Mandal R, Jackson D, Sligl W, Grant MB, Penninger JM, Borchers CH, Wishart DS, Prasad V, Oudit GY. Cell Rep Med. 2023 Nov 21;4(11):101254. doi: 10.1016/j.xcrm.2023.101254. Epub 2023 Oct 26. PMID: 37890487; PMCID: PMC10694626.

López-Hernández, Y., Monárrez-Espino, J., López, D.A.G., Zheng, J., Borrego, J.C., Torres-Calzada, C., Elizalde-Díaz, J.P., Mandal, R., Berjanskii, M., Martínez-Martínez, E., López, J.A. and Wishart, D.S. (2023). The plasma metabolome of long COVID patients two years after infection. Sci. Rep. 13(1):12420.

Wang, K., Khoramjoo, M., Srinivasan, K., Gordon, P.M., Mandal, R., Jackson, D., Sligl, W., Grant, M.B., Penninger, J.M., Borchers, C.H. and Wishart, D.S. (2023). Sequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID. Cell Rep. Med. 4(11):101254.

Wang, K., Khoramjoo, M., Srinivasan, K., Mandal, R., Borchers, C., Wishart, D., Prasad, V. and Oudit, G. (2023). Machine learning analysis of long COVID multiomics reveals clinical phenotypes and prognostic biomarkers. Can. J. Diabetes 47(7): S1.

Khoramjoo, M., Srinivasan, K., Wang, K., Wishart, D., Prasad, V., and Oudit, G. Y. (2024). Protocol to identify biomarkers in patients with post-COVID condition using multi-omics and machine learning analysis of human plasma. STAR Protoc. 5(2): 103041.

Khoramjoo, M., Wang, K., Srinivasan, K., Gheblawi, M., Mandal, R., Rousseau, S., Wishart, D., Prasad, V., Richer, L., Cheung, A.M. and Oudit, G.Y. (2024) Plasma taurine level is linked to symptom burden and clinical outcomes in post-COVID condition. PLoS One 19(6): e0304522.

Vergara A, Wang K, Colombo D, Gheblawi M, Rasmuson J, Mandal R, Del Nonno F, Chiu B, Scholey JW, Soler MJ, Wishart DS, Oudit GY. Clin Kidney J. 2022 Sep 21;16(2):272-284. doi: 10.1093/ckj/sfac215. PMID: 36751625; PMCID: PMC9494506.

Fraser, D.D., Slessarev, M., Martin, C.M., Daley, M., Patel, M.A., Miller, M.R., Patterson, E.K., O'Gorman, D.B., Gill, S.E., Wishart, D.S., Mandal, R. and Cepinskas, G. (2020) Metabolomics profiling of critically ill Coronavirus Disease 2019 patients: Identification of diagnostic and prognostic biomarkers. Crit. Care Explor. 2(10):e0272.

Haratian, A., Fazelinia, H., Maleki, Z., Ramazi, P., Wang, H., Lewis, M.A., Greiner, R. and Wishart, D. (2021) Dataset of COVID-19 outbreak and potential predictive features in the USA. Data Brief. 38:107360.

López-Hernández, Y., Monárrez-Espino, J., Oostdam, A.H., Delgado, J.E.C., Zhang, L., Zheng, J., Valdez, J.J.O., Mandal, R., González, F.L.O., Moreno, J.C.B., Trejo-Medinilla, F.M., López, J.A., Moreno, J.A.E. and Wishart, D.S. (2021) Targeted metabolomics identifies high performing diagnostic and prognostic biomarkers for COVID-19. Sci. Rep. 11(1):14732. Erratum Sci. Rep.12(1):1673 (2022).

Ramazi, P., Haratian, A., Meghdadi, M., Mari Oriyad, A., Lewis, M.A., Maleki, Z., Vega, R., Wang, H., Wishart, D.S. and Greiner, R. (2021) Accurate long-range forecasting of COVID-19 mortality in the USA. Sci. Rep. 11(1):13822.

Herrera-Van Oostdam, A.S., Castañeda-Delgado, J.E., Oropeza-Valdez, J.J., Borrego, J.C., Monárrez-Espino, J., Zheng, J., Mandal, R., Zhang, L., Soto-Guzmán, E., Fernández-Ruiz, J.C., Ochoa-González, F., Trejo Medinilla, F.M., López, J.A., Wishart, D.S., Enciso-Moreno, J.A. and López-Hernández, Y. (2021) Immunometabolic signatures predict risk of progression to sepsis in COVID-19. PLoS One. 16(8):e0256784.

Vergara, A., Wang, K., Colombo, D., Gheblawi, M., Rasmuson, J., Mandal, R., Del Nonno, F., Chiu, B., Scholey, J.W., Soler, M.J., Wishart, D.S. (2023) Urinary angiotensin-converting enzyme 2 and metabolomics in COVID-19-mediated kidney injury. Clinical Kidney Journal, 16(2): 272-284,

García-López, D. A., Monárrez-Espino, J., Borrego-Moreno, J. C., Zheng, J., Mandal, R., Torres-Calzada, C., Oropeza-Valdez, J. J., Tenório Nunes, A., Sánchez Rodríguez, S. H., López, J. A., Calzada Rodríguez, B. E., Wishart, D. S., & López-Hernández, Y. (2025). Comprehensive clinical and metabolomics profiling of COVID-19 Mexican patients across three epidemiological waves. Frontiers in molecular biosciences, 12, 1607583.

Ezeugwu VE, Adamko D, van Eeden C, Dubeau A, Turvey SE, Moraes TJ, Simons E, Subbarao P, Wishart DS, Mandhane PJ. Sleep Med. 2022 Dec;100:472-478. doi: 10.1016/j.sleep.2022.09.015. Epub 2022 Sep 24. PMID: 36252416.

López-Hernández, Y.; Lima-Rogel, V.; Mandal, R.; Zheng, J.; Zhang, L.; Oler, E.; García-López, D.A.; Torres-Calzada, C.; Mejía-Elizondo, A.R.; Poelsner, J.; et al. Metabolites 2024, 14, 41. https://doi.org/10.3390/metabo14010041

Vu K, Lou W, Tun HM, Konya TB, Morales-Lizcano N, Chari RS, Field CJ, Guttman DS, Mandal R, Wishart DS, Azad MB, Becker AB, Mandhane PJ, Moraes TJ, Lefebvre DL, Sears MR, Turvey SE, Subbarao P, Scott JA, Kozyrskyj AL. Gastroenterology. 2021 Jan;160(1):128-144.e10. doi: 10.1053/j.gastro.2020.08.053. Epub 2020 Sep 16. PMID: 32946900.

Bridgman SL, Malmuthuge N, Mandal R, Field CJ, Haqq AM, Mandhane PJ, Moraes TJ, Turvey SE, Simons E, Subbarao P, Scott JA, Wishart DS, Kozyrskyj AL. Int J Obes (Lond). 2022 Sep;46(9):1712-1719. doi: 10.1038/s41366-022-01183-3. Epub 2022 Jul 15. PMID: 35840772.

Shanmuganathan M, Sarfaraz MO, Kroezen Z, Philbrick H, Poon R, Don-Wauchope A, Puglia M, Wishart D, Britz-McKibbin P. Front Mol Biosci. 2021 Aug 3;8:676349. doi: 10.3389/fmolb.2021.676349. PMID: 34414211; PMCID: PMC8370474.

Zaidi D, Huynh HQ, Carroll MW, Mandal R, Wishart DS, Wine E. J Pediatr Gastroenterol Nutr. 2020 Nov;71(5):624-632. doi: 10.1097/MPG.0000000000002848. PMID: 33093369.

Fraser DD, Slessarev M, Martin CM, Daley M, Patel MA, Miller MR, Patterson EK, O'Gorman DB, Gill SE, Wishart DS, Mandal R, Cepinskas G. Crit Care Explor. 2020 Oct 21;2(10):e0272. doi: 10.1097/CCE.0000000000000272. PMID: 33134953; PMCID: PMC7587450.

López-Hernández Y, Monárrez-Espino J, Oostdam AH, Delgado JEC, Zhang L, Zheng J, Valdez JJO, Mandal R, González FLO, Moreno JCB, Trejo-Medinilla FM, López JA, Moreno JAE, Wishart DS. Sci Rep. 2021 Jul 19;11(1):14732. doi: 10.1038/s41598-021-94171-y. Erratum in: Sci Rep. 2022 Jan 25;12(1):1673. PMID: 34282210; PMCID: PMC8290000.

Herrera-Van Oostdam AS, Castañeda-Delgado JE, Oropeza-Valdez JJ, Borrego JC, Monárrez-Espino J, Zheng J, Mandal R, Zhang L, Soto-Guzmán E, Fernández-Ruiz JC, Ochoa-González F, Trejo Medinilla FM, López JA, Wishart DS, Enciso-Moreno JA, López-Hernández Y. PLoS One. 2021 Aug 30;16(8):e0256784. doi: 10.1371/journal.pone.0256784. PMID: 34460840; PMCID: PMC8405033.

Celaya-Padilla JM, Villagrana-Bañuelos KE, Oropeza-Valdez JJ, Monárrez-Espino J, Castañeda-Delgado JE, Oostdam ASH, Fernández-Ruiz JC, Ochoa-González F, Borrego JC, Enciso-Moreno JA, López JA, López-Hernández Y, Galván-Tejada CE. Diagnostics (Basel). 2021 Nov 25;11(12):2197. doi: 10.3390/diagnostics11122197. PMID: 34943434; PMCID: PMC8700648.

López-Hernández Y, Monárrez-Espino J, López DAG, Zheng J, Borrego JC, Torres-Calzada C, Elizalde-Díaz JP, Mandal R, Berjanskii M, Martínez-Martínez E, López JA, Wishart DS. Sci Rep. 2023 Aug 1;13(1):12420. doi: 10.1038/s41598-023-39049-x. PMID: 37528111; PMCID: PMC10394026.

Tobolski, D., Zwierzchowski, G., Wójcik, R., Haxhiaj, K., Wishart, D. S., and Ametaj, B. N. (2024). Metabolic fingerprinting of blood and urine of dairy cows affected by Bovine Leukemia Virus: a mass spectrometry approach. Metabolites 14(11): 624.

Boullier, C., Lamaze, F.C., Haince, J.F., Bux, R.A., Orain, M., Zheng, J., Zhang, L., Wishart, D.S., Bossé, Y., Manem, V.S. and Joubert, P. (2024) Metabolomic profiling of pulmonary neuroendocrine neoplasms. Cancers, 16(18): 3179.

JCO 41, 3071-3071(2023). DOI:10.1200/JCO.2023.41.16_suppl.3071

Zhang, L., Zheng, J., Ismond, K. P., MacKay, S., LeVatte, M., Constable, J., Isaac Alatise, O., Peter Kingham, T., & Wishart, D. S. (2023). Cancer Biomarkers, 36(1), 17–30. https://doi.org/10.3233/cbm-220034

Wishart, D.S. (2022) Metabolomics and the multi-omics view of cancer. Metabolites, 12(2):154.

Joubert, P., Wishart, D., Haince, J.F., Bach, H., Bux, R., Tappia, P., and Ramjiawan, B. (2022) 912P Metabolomic profiling for the early detection of lung cancer. Ann. Oncol. 33: S965.

Anwar, M. A., Keshteli, A. H., Yang, H., Wang, W., Li, X., Messier, H. M., Cullis, P. R., Borchers, C. H., Fraser, R., and Wishart, D. S. (2024). Blood-based multiomics-guided detection of a precancerous pancreatic tumor. OMICS 28(4):182–192.

Ramaboli, M. C., Ocvirk, S., Khan Mirzaei, M., Eberhart, B. L., Valdivia-Garcia, M., Metwaly, A., Neuhaus, K., Barker, G., Ru, J., Nesengani, L. T., Mahdi-Joest, D., Wilson, A. S., Joni, S. K., Layman, D. C., Zheng, J., Mandal, R., Chen, Q., Perez, M. R., Fortuin, S., Gaunt, B., Wishart, D., Methé, B., Haller, D., Li, J.V., Deng, L., Swart, R., and O’Keefe, S. J. D. (2024). Diet changes due to urbanization in South Africa are linked to microbiome and metabolome signatures of Westernization and colorectal cancer. Nat. Commun.15(1): 3379.

Almanza-Aguilera, E., Martínez-Huélamo, M., López-Hernández, Y., Guiñón-Fort, D., Guadall, A., Cruz, M., Perez-Cornago, A., Rostgaard-Hansen, A. L., Tjønneland, A., Dahm, C. C., Katzke, V., Schulze, M. B., Masala, G., Agnoli, C., Tumino, R., Ricceri, F., Lasheras, C., Crous-Bou, M., Sánchez, M.-J., Aizpurua-Atxega, A., Guevara, M., Tsilidis, K. K., Chatziioannou, A. C., Weiderpass, E., Travis, R. C., Wishart, D. S., Andrés-Lacueva, C. and Zamora-Ros, R. (2024). Prediagnostic plasma nutrimetabolomics and prostate cancer risk: a nested case-control analysis within the EPIC study. Cancers 16(23): 4116.

Bhattacharyya, D., LeVatte, M. A., Singh, U., Issac, F., Karim, M., Ali, S., Sieben, A., Huang, S., and Wishart, D. S. (2024). A novel colorimetric assay for the detection of urinary N1, N12-diacetylspermine, a known biomarker for colorectal cancer. Anal. Biochem. 697: 115717.

Joubert, P., Zhang, L., Boullier, C., Plante, S., Biardel, S., Mandal, R., Wishart, D.S., Pelletier, A., Bux, R.A., Haince, J.F. and Maksymiuk, A.W. (2023). Large retrospective validation study of metabolomic biomarkers for resectable lung cancer detection and risk assessment. J. Clin. Oncol., 41(16_suppl): 3071-3071.

Zhang, L., Zheng, J., Bux, R. A., Haince, J. F., Torres-Calzada, C., Mandal, R., Maksymiuk, A., Huang, G., Tappia, P. S., Joubert, P., Rolfo, C. D., & Wishart, D. S. (2025). Clinical Validation of Plasma Metabolite Markers for Early Lung Cancer Detection. International journal of molecular sciences, 26(10), 4519.

López-Hernández, Y., Andres-Lacueva, C., Wishart, D. S., Torres-Calzada, C., Martínez-Huélamo, M., Almanza-Aguilera, E., and Zamora-Ros, R. (2025). Prostate cancer risk biomarkers from large cohort and prospective metabolomics studies: A systematic review. Transl. Oncol. 51: 102196.

Carrillo MP, Bedrossiantz J, Zheng J, Mandal R, Wishart DS, Gómez-Canela C, Vila-Costa M, Prats E, Piña B, Raldúa D. Ecotoxicol Environ Saf. 2023 Dec 26;270:115888. doi: 10.1016/j.ecoenv.2023.115888. Epub ahead of print. PMID: 38150752.

Banoei MM, Lee CH, Hutchison J, Panenka W, Wellington C, Wishart DS, Winston BW; Canadian biobank, database for Traumatic Brain Injury (CanTBI) investigators, the Canadian Critical Care Translational Biology Group (CCCTBG), the Canadian Traumatic Brain Injury Research, Clinical Network (CTRC). Crit Care. 2023 Jul 22;27(1):295. doi: 10.1186/s13054-023-04573-9. PMID: 37481590; PMCID: PMC10363297.

Keshteli AH, Valcheva R, Nickurak C, Park H, Mandal R, van Diepen K, Kroeker KI, van Zanten SV, Halloran B, Wishart DS, Madsen KL, Dieleman LA. Nutrients. 2022 Aug 11;14(16):3294. doi: 10.3390/nu14163294. PMID: 36014800; PMCID: PMC9414437.

Zaidi, D., Huynh, H.Q., Carroll, M.W., Mandal, R., Wishart, D.S. and Wine, E. (2020) Gut Microenvironment and Bacterial Invasion in Pediatric Inflammatory Bowel Diseases. J. Pediatr. Gastroenterol. Nutr. 71(5):624-632.

Keshteli, A.H., Valcheva, R., Nickurak, C., Park, H., Mandal, R., van Diepen, K., Kroeker, K.I., van Zanten, S.V., Halloran, B., Wishart, D.S., and Madsen, K.L. (2022) Anti-inflammatory diet prevents subclinical colonic inflammation and alters metabolomic profile of ulcerative colitis patients in clinical remission. Nutrients, 14(16): 3294.

Suarez, R.G., Guruprasad, N., Tata, G., Zhang, Z., Focht, G., Navas-López, V., Koletzko, S., Griffiths, A.M., Wishart, D. and Wine, E. (2023). A164 Identifying the most important predictors to correlate serum metabolites with MRE changes in patients with pediatrics Crohn disease. J. Can. Assoc. Gastroenterol. 6(Suppl. 1):10.

Suarez, R.G., Guruprasad, N., Tata, G., Zhang, Z., Focht, G., McClement, D., Navas-López, V.M., Koletzko, S., Griffiths, A.M., Ledder, O., de Ridder, L. Wishart, D., Nichols, B., Gerasimidis, K., Turner, D., and Wine, E. (2024) Serum metabolites relate to mucosal and transmural inflammation in pediatric Crohn Disease. J. Crohns Colitis 18(11): 1832–1844.

Haxhiaj, K., Wishart, D. S. and Ametaj, B. N. (2022) Mastitis: What it is, current diagnostics, and the potential of metabolomics to identify new predictive biomarkers. Diary, 3(4):722-746,